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GLP-1 drugs as a class have shown mixed results in heart failure populations

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Salehi noted that in the clinical trials, depending on the drug, only about five to ten percent of patients stopped using them, but when you go to the real-world studies, almost actually 50 percent of people, they stop these drugs by six months to 12 months. Salehi explained that its unclear if that is because of the side effects, though they could be playing a role

Researchers who escalated too quickly bore the brunt of gastrointestinal side effects, while those who followed the standard four-week titration intervals reported significantly better tolerability