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STEP-1 set the standard at -14,9% in 2021

Non-GLP-1 agents are most appropriate for patients unable to tolerate GLP-1 medications, those with GLP-1 contraindications (such as personal or family history of medullary thyroid carcinoma), or individuals requiring different metabolic pathways

Think of L-Carnitine as their shuttle service

A 2025 pilot study published in PubMed confirmed short-term tolerance in 2 participants at 20mg intravenously, though the sample size remains too limited for definitive safety conclusions

Pliva was acquired by Barr Pharmaceuticals, which was later acquired by Teva Pharmaceutical Industries