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Nutritional deficiencies, particularly in vitamins A, D, and E, have been associated with increased acne severity

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This means that reserves are maintained in our body for up to 5 years, and are not necessarily excreted via urine, unlike other water-soluble vitamins

And that is not observed: Children with IGF1 defects suffer from far more severe fetal growth retardation with birth weight SDS around -4 and birth length SDS of -5 to -6 (reviewed in (58)

PSV-11 determining relative bioavailability of commercially available rumen protected-methionine products in lactating dairy cows