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Natural OXM peptide has both neuroprotective and neurotrophic effects against oxidative stress and glutamate toxicity in cultured primary cortical neurons of rat and SH-SY5Y cells, two cellular models that are broad applied to evaluating neuroprotective and neurotrophic effects of experimental therapeutics in the development of neuroprotective agents (127)

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Giannoudis PV, Panteli M, Calori GM

STEP 3 had more frequent study visits weekly during the 16-week dose escalation period, every 2 weeks through week 24, then every 4 weeks until the end of the maintenance period