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Fatigue ranks among the more common side effects reported by patients taking GLP-1 medications like Wegovy, affecting approximately 1015% of users in clinical trials

6 Mechanisms of intestinal-brain signaling The gut-brain axis is a bidirectional communication system linking the gastrointestinal (GI) tract and the central nervous system (CNS), which plays a pivotal role in maintaining homeostasis across many physiological processes (Arneth, 2018