In the presence of oxygen and transition metals like iron and copper, dietary phenolic compounds, including flavonoids, can act as pro-oxidants by catalyzing the redox cycle of phenolic compounds
over the past six years, based on data from the FDA Adverse Event Reporting System (FAERS)
11,190,192,193 To note, real world observational data suggest that average weight loss is lower than that seen in randomised controlled trials due to a combination of lower achieved dosages, treatment interruptions and high discontinuation rates (up to 2050% within the first year)
Additionally, a recent research study investigates how 4-Octyl itaconate (OI), a form of itaconate functioning as a KEAP1 inhibitor, affects DSS-induced UC in mice (264)
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