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Alterations in the volume of distribution and clearance resulting from other mechanisms of action (eg, reduced fat mass, changes in cytochrome P450 activity, and glomerular filtration rate) are key factors in determining pharmacokinetics

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The 5-LOX enzyme, found in CD163 + tumor-associated macrophages, promotes the formation of hepatocellular carcinoma (HCC) by generating leukotrienes that augment cancer cell proliferation and stem cell capabilities [275]

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