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Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)

Another arginine-related pathway involves carbamoyl phosphate synthetase 1 (CPS1), a key enzyme in the urea cycle that regenerates arginine through citrulline recycling

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Gently swirl or invert to dissolve do not vortex or shake vigorously, as this can disrupt the disulfide bond and active loop conformation