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However, it's important to note that most of the current understanding is based on preliminary research, primarily from animal studies

The effective blood-brain barrier mechanism impeding the transport of monoamines has been attributed to both the presence of tight junctions cementing adjacent endothelial cells of the cerebral capillary walls, along with high concentrations of dopa decarboxylase and monoamine oxidase (MAO) in the cerebral capillary endothelium (Bertler et al, 1966

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Some cases need medication support or dose review

From bench to bedside: What do we know about hormone receptor-positive and human epidermal growth factor receptor 2-positive breast cancer