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Furthermore, gene expression analysis of adipocytes differentiated from lipedema-derived stem cells (derived from Stages 13 of lipedema) revealed a significant upregulation of adipogenic markers, such as leptin and PPAR-, compared to healthy non-lipedema adipocytes suggesting an increased adipogenic differentiation potential in lipedema tissue (Al-Ghadban et al., 2020a)

Gut Microbes 14 , 2018899 (2022)

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Weeks 1-6 Loading Phase Topical: twice-daily application over treatment zones Injection: 250500 g sub-Q, 35 weekly Weekly RN check-ins to track skin metrics, pain scores, and hair density photos

Treatment Schedule and Follow-Up Intralesional biologic injections are administered at 23-week intervals fora total of four treatment sessions (Weeks 0, 3, 6, and 9)