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This is known as intestinal dysmotility

[1] Whilst vitamin B12 deficiency can cause serious health consequences including megaloblastic anaemia and neurological damage, supplementation is generally considered safe

Additionally, keratinocytes and Langerhans cells (LCs), release cytokines such as IL-10, IL-12, IL-18, IL-23, IL-17 and IL-22 and thymic stromal lymphopoietin (TSLP), leading to an enhanced Th2-type inflammatory response (48, 50, 51)

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So NACs timing isnt arbitrary