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Pagali has received the Mayo Clinic CTSA (Mayo Clinic Small grants) through grant number UL1TR002377 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH)

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The drug performed significantly better than a placebo, with people on the highest dose losing around 10% of their baseline body weight on average

Malignant peripheral nerve sheath tumors may appear de novo or may develop from the transformation of a benign neural neoplasm, mainly from a plexiform neurofibroma, which occurs almost exclusively in neurofibromatosis type 1 patients

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