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No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern

USA 114 , 1254212547 (2017)

She added that the consistency of the decreased likelihood of dementia diagnosis across the different medications was particularly noteworthy. Past studies have reported associations between GLP-1 receptor agonists and dementia, with some suggesting a reduced dementia risk after starting the medication and others indicating variability depending on how these medications cross the blood-brain barrier, Bartlet and colleagues wrote

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