In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, and WARNINGS]
Histology confirmed increased angiogenesis, greater fibroblast density, and improved collagen organization
All chronic diseases, including COVID-19 with the long-COVID-19-syndrome (271), are characterized by the presence of persistent chronic inflammation and sustained generation of reactive oxygen and nitrogen species that when confronted with inadequate antioxidant defenses (likely leading components of anti-inflammaging) precipitate excessive oxidative stress
Theranostics 2018;8:23755
The peptide's natural occurrence in the body, well-established safety profile from decades of topical use and clinical research, and remarkable breadth of beneficial biological effects make it a compelling example of a naturally derived regenerative peptide with both proven cosmetic applications and ongoing exploration of broader therapeutic potential
