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Metalloproteinases can digest collagen and elastin, weakening the skin and causing sag

CoQ10 has two forms: ubiquinone and ubiquinol

5.2 Reduction of oxidative stress and endoplasmic reticulum stress Chronic hyperglycemia and endothelial activation drive excessive generation of ROS, promoting mitochondrial dysfunction, endothelial apoptosis, and reduced NO bioavailability