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Important safety considerations include a boxed warning for medullary thyroid carcinoma risk (contraindicated in patients with personal/family history of MTC or Multiple Endocrine Neoplasia syndrome type 2), and warnings regarding pancreatitis, gallbladder disease, and hypoglycemia risk when used with insulin or sulfonylureas
The most common mild reactions to injections are redness or itchiness at the injection site or mild diarrhea
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The first approach used only the adjudicated cases (GLP-1 n = 13 and placebo n = 5)
Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin
Better glucose control, modest weight reduction, and support for healthier eating patterns may contribute to improved long-term metabolic management
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