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People who plan to get frequent injections over long periods long-term safety is unknown

Potential Side Effects of Creatine Studies examining the effects of long-term creatine supplementation have demonstrated no negative effects on liver, kidney, blood, bone, brain, or muscle function

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260 Conversely, TRAF6-mediated ubiquitination of HK2 facilitates its degradation via autophagy, reducing glycolytic activity