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A related study revealed that the peripheral administration of D-glucose significantly enhances morphine-mediated antinociception, suggesting a synergistic interaction between the glucose and opioid pathways 48
The tolerable upper intake level for adults is 2000 mg/day, above which gastrointestinal upset and, rarely, kidney-stone risk increase.[5]Vitamin C Fact Sheet NIH Office of Dietary Supplements View source A head-to-head comparison of liposomal and non-liposomal ascorbic acid found no safety advantage that would change daily-use guidance.[6]Liposomal vs Non-Liposomal Vitamin C Journal of Liposome Research (2021) View source Stay at or below 2000 mg/day unless a clinician advises otherwise
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