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As described above, this experimental structure (PDB ID: 4ZGM [29, 52]) was used as the template for structural modeling by Modeller [44] and ligand-receptor binding affinity calculations by Prodigy [45, 46], as described in [47]

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The results were life-changing

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A 2017 study examined cultured vascular endothelial cells, a chick chorioallantoic membrane model, and a standardized rat hind-limb ischemia model