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Dardano A, Bianchi C, Garofolo M, Del Prato S

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However, many researchers prefer morning administration before breakfast to maximize metabolic effects during the active day period

Specific considerations for autoimmune disease patients: Delayed gastric emptying may affect absorption of oral medications, including some immunosuppressants Monitoring challenges in distinguishing disease activity from medication side effects Importance of maintaining stable immunosuppression regimens Patients should seek immediate medical attention for severe, persistent abdominal pain (potential pancreatitis or gallbladder disease), vision changes, severe vomiting/dehydration, neck mass/hoarseness, or allergic reactions