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How the series is organized 33 compounds are a lot to navigate

Beyond binding to the intended targets (e.g., TAA and CD3 for a TCE), additional engineering in the Fc region including point mutations in the Fc domain are also often incorporated in IgG-based approaches to inhibit Fc receptors (FcR) IIII binding, improve PK (pharmacokinetics) by reducing liver uptake and eliminate antibody-dependent cell-mediated cytotoxicity (ADCC)

Our response to that inflammation should be appropriate, which is to build immunity without going overboard

Tirzepatide (Mounjaro, Zepbound) Dual GLP-1 & GIP receptor agonist for enhanced weight loss and fat metabolism

doi:10.1101/gad.237081.113