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In one embodiment the PDE-5 inhibitor is administered between 5 and 45 minutes prior to the administration of PT-141 , preferably between about 10 and 30 minutes prior to the administration of PT-141

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Tirzepatide, a dual GLP-1/GIP receptor agonist, has emerged as a promising treatment avenue because sustained weight reduction of 1522% can substantially lower sleep apnea severity and breathing event frequency

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