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In these various investigations, HG influences several key pathways, including anti-inflammatory, anti-oxidant, anti-apoptosis, and anti-shock mechanisms, as illustrated in Fig

These experimental results fully demonstrate that NP4 can promote the maturation of DCs

The different CRP isoforms, nCRP, non-native pentameric CRP (nnCRP) and mCRP (175178, 181184), may explain their protective and destructive effects, with nCRP being primarily antiinflammatory inducing Th2/M2 responses, while mCRP being typically proinflammatory inducing Th1/M1 responses (170, 185189)

doi: 10.1016/j.joca.2023.01.573 167 GuoPGaoXNelsonALHuardMLuAHambrightWSet al