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In addition to the common clinical manifestations shared with CCDS1, CCDS2 is characterized by specific behavioral disorders, including autistic behavior and self-mutilation [39]

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On the other hand, cholesterol is also highly concentrated in PC cells [150], and CAFs upregulate its synthesis and the steroid biosynthesis pathway [151], possibly by proinflammatory cytokines and chemokines, not via oncometabolite signaling

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