Tsukasaki and Takayanagi, 2019)
Given that the key role of GPX4 for the maintenance of neuronal function, selective deletion of GPX4 in the brain contributes to cognitive impairment and neurodegeneration ( Collectively, our present work shows that lapatinib, a well-known anti-cancer drug, protects brain against epileptic seizures
Safety of insulin analogs during pregnancy: a meta-analysis
Key Research Areas for 5-Amino-1MQ NNMT enzyme inhibition assays IC50 characterisation, selectivity profiling, and 1-MNA production quantification NAD+ salvage pathway studies nicotinamide flux, NMN and NAD+ pool modulation in vitro SAM/SAH methyl-donor pathway research epigenetic methylation capacity and histone modification studies Adipocyte biology lipogenesis suppression, adipocyte size, white adipose mass, and lipid storage pathway studies SIRT1 and SIRT3 activation and downstream pathway research insulin sensitivity, gluconeogenesis, mitochondrial function Skeletal muscle function and sarcopenia pathway research muscle strength, endurance, and mitophagy-related studies in aged models Gut microbiome modulation research in diet-induced obesity models Cancer cell biology NNMT-overexpressing cell line studies, anti-proliferative pathway investigations Cardiovascular metabolic pathway research homocysteine, SIRT activity, NF-B and STAT3 inflammatory signalling Comparative NNMT inhibitor studies 5-Amino-1MQ vs
Applying a clinically meaningful number or difference helps to prevent trials from being declared positive based solely on statistical significance
