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Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line

Essential for microdosing protocols or high-concentration vials where tiny volume differences matter

The consistency of the preclinical data across multiple studies and laboratories supports the mechanistic hypothesis

Nunes J, Andrieux P, Brochet P, Almeida RR, Kitano E, Honda AK, Iwai LK, Andrade-Silva D, Goudenge D, Alcntara Silva KD, Vieira RS, Levy D, Bydlowski SP, Gallardo F, Torres M, Bocchi EA, Mano M, Santos R, Bacal F, Pomerantzeff P, Laurindo F, Teixeira PC, Nakaya HI, Kalil J, Procaccio V, Chevillard C, Cunha-Neto E

Light exposure also degrades semaglutide