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The collagen synthesis stimulation represents GHK-Cu's most studied effect, with research showing increased fibroblast activity, enhanced collagen type I and III production, and improved dermal matrix organization during treatment periods

Acknowledgements We thank Diamond Light Source for beamtime (proposal mx19946), and the staff of beamline I03 for assistance

The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality

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Comment: A few commenters raised concerns that the Safety of Care measure group is based on a limited set of measures, which could reduce comparability across hospitals and may not fully capture the complexity of patient safety performance