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Studies treating mild to moderate B12 deficiency in older people have failed to provide cognitive benefits: A clinical trial from the Netherlands measured the cognitive response to B12 supplements in people 70 years old with mild B12 deficiency and MMA levels 320 nmol/l (average: ~450 nmol/l)

doi:10.2174/138161211796196954 Sikiric P, Hahm KB, Blagaic AB, et al

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However, the limited application of immunotherapy drugs and the fact that only a third of ovarian cancer patients respond to them have prompted the exploration of alternative approaches (Liang et al., 2019a)

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