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A series of rationally designed modifications included the interchange of specific GIP-derived amino acids, the addition of the C-terminally extended residues from the reptilian GLP-1R agonist, exendin-4, and select non-canonical amino acids at position 2 and 20

Mounjaro (Tirzepatide) is a prescription medication that is primarily used to treat type 2 diabetes

PMC2696075 Pizzorno J

doi: 10.4014/jmb.1205.05018 185 FikriBRidhaNRPutriSHSalekedeSBJuliatyATanjungCet al

A patient with a genetic profile showing reduced GLP1R signaling capacity might derive stronger weight-loss results from tirzepatide than someone with robust baseline GLP-1 sensitivity