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With that promise comes a practical question: What about side effects

However, the accelerated approval pathway means that evidence is still interim: while part one of the ESSENCE trial demonstrated improvement in liver scarring and inflammation, it does not yet show whether semaglutide reduces the risk of serious outcomes such as cirrhosis, liver failure or liver cancer

Consequently, it is essential to prioritize shared decision-making and individualized risk-benefit assessments for prescribing GLP-1 RAs, while avoiding misuse with off-label indications

The withdrawal pattern typically involves gradual return of appetite over 2 to 4 weeks, followed by weight regain over the subsequent months

Some people notice a decrease in appetite within the first week or two, while for others it may be more gradual as the dose is titrated up