This suggests that the overall rate of glucose metabolism is unaffected by methylene blue, but a greater proportion (87%) is by way of the decarboxylation pathway
That is a big part of it
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The drug usually has strong hydrophobicity, and the water solubility of the PEG fragment helps to increase the solubility of the linker-drug complex in physiological media and improve the pharmacokinetic properties of the entire ADC