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These reports typically describe: Low mood or emotional flatness Reduced motivation or interest in activities Anxiety or irritability Changes in emotional responsiveness It is important to contextualise these reports within the broader patient experience

The design of drug targets for ASCT2 typically follows a substrate analogue approach, wherein substrate analogues function as competitive inhibitors, thereby reducing the uptake of essential amino acids by cancer cells

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J Cell Biol 2013

The worsening of symptoms after stopping glutathione reflects the return of the underlying condition elevated oxidative stress from chronic disease, mitochondrial dysfunction, or metabolic pathology that glutathione was temporarily mitigating