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Otherwise, if increased angiogenesis appears as dysregulation, as a likely possibility, regardless of beneficial effects, there is a considerable probability that increased angiogenesis precedes the complications and impedes uncontrolled VEGF, the egr-1 gene, carcinoma, and the NO-system [1]

References : National Center for Biotechnology Information

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[1] Research in animal models has also been interesting

Diabetes or metabolic syndromes: People living with diabetes or metabolic syndromes, such as high blood pressure, high blood sugar, excess body fat around the waist, and irregular cholesterol levels, may also experience inflammation in the body, which can impact the health of the shoulder and rotator cuff, particularly leading to adhesive capsulitis (frozen shoulder)