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Moreover, subsequent research should investigate the prospective contributions of these interventions beyond sarcopenia, particularly in the realms of preventing or alleviating age-related vascular aging, metabolic syndrome, and frailty

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Molecular modeling indicates that the substitution of a valine to glutamic acid at residue 411 reduces the binding affinity of linolenic acid, a reported exogenous ligand for the NHR-49 ortholog, HNF4, as well as other potential fatty acid binding partners with comparable structure (Supplementary Fig