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However, the detailed molecular mechanisms by which these factors suppress DENV replication remain to be elucidated

This is not a moment to replicate past LoE playbooks, its a moment to redefine them

PubMed Mohammad YM, Raslan IR, Al-Hussain FA

Subcutaneous administration suffers from: Lower bioavailability Variable absorption Different pharmacokinetics Which means the systemic exposure of DSIP via subcutaneous administration is not equivalent to what is achieved with intravenous infusion

Gastrointestinal adverse effects (AEs): 74% versus 48% (PC), number needed to harm (NNH) = 3