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The study also showed several cardiometabolic benefits of semaglutide with significant improvement in hemoglobin A1C, body weight, and cholesterol reduction compared to placebo

18,22 Pharmacological intervention is therefore usually required to assist in long-term weight loss in obese patients, and there several available drugs for this but they often exhibit insufficient efficacy and dubious safety

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Aim of this review is to give experimental and clinical supports on the possible role of GLP-1 in PCOS pathogenesis and treatment, independently on its weight-loss effect