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Among the innate components, innate immune cells, such as macrophages, neutrophils and mast cells, are capable of producing a range of cytokines that regulate bone metabolism in skeletal diseases (Walsh et al., 2018

5 Limitations and future directions of research Given the scope of the present study, several key factors warrant acknowledgment: First, bridging the translational gap between animal models and human clinical applications is challenging

Therefore, strain identification and description, production process and quality control, clinical trials and efficacy verification, safety assessment, clear labeling and instructions, and continuous monitoring and feedback mechanisms need to be further improved in the regulatory aspect of the safety of probiotics use

In this case, a B12 injection might help

Gattermann, N., Muckenthaler, U., Kulozik, A