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Previously called morbid obesity

Considering the network that bi-directionally links obesity and insulin resistance in the pathogenesis of PCOS, it seems to be particularly appealing a new approach producing, at the same time, satisfactory and permanent weight loss, improvement in insulin resistance and in metabolic profile, with additional favourable outcomes on reproductive and cardiovascular systems (19)

Mouillet-Richard, S

Retatrutide is an investigational triple agonist activating GLP-1, GIP, and glucagon receptors simultaneously, with Phase 2 trials using once-weekly subcutaneous doses of 1 mg to 12 mg

Ranked retatrutide among new weight loss drugs for its impact in clinical trials, compared to semaglutide, tirzepatide, and orlistat