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More articles by Optimum Patient Care Feb 28, 2026 Harnessing Specialised Algorithms To Detect Rare Disease in UK Primary Care: CAPTURED Trial OPRI (Observational and Pragmatic Research International Limited) is excited to launch the OPC (Optimum Patient Care) Dec 19, 2025 Merry Christmas from Optimum Patient Care As 2025 draws to a close, we wish to thank our followers for their continued support and engagement with Optimum Nov 28, 2025 Major GOLD Guideline Change for COPD The Impact of OPRI, the University of Exeter, and OPCRD Data The 2026 update to the GOLD (Global Initiative for Chronic Feb 21, 2025 Improving patient outcomes through quality improvement (QI) methodologies: A systematic approach Introduction As novel interventionsranging from drugs to software and clinical techniquesbecome increasingly targeted Feb 4, 2025 Optimum Patient Care: The Challenge and Aim OPC senior leadership January 2025 The healthcare sector is very good at innovation
Beyond histological changes, both regions displayed a consistent enteric nervous system imbalance, characterised by a dose-dependent reduction in neurons expressing neuronal nitric oxide synthase (nNOS), cocaine- and amphetamine-regulated transcript (CART), vesicular acetylcholine transporter (VAChT) and vasoactive intestinal peptide (VIP), and a corresponding increase in galanin and substance P neurons, indicating a shift toward a pro-inflammatory neuronal profile
