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They are essentially the same

To investigate copper-dependent signalling pathways involved in cellular growth, differentiation, and tissue remodelling

The supernatants were collected and diluted 1:10 in KRB for the insulin detection assay

However, there are also cases when additional factors such as lack of sleep, poor diet, and deficiency of other vitamins like iron, folate, and others, contribute to the issue

doi:10.22038/IJBMS.2020.44254.10378