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(117) proposed that the degeneration of spinal components is associated with gut microbiota anomalies and separately categorized osteoporosis, synovial osteoarthritis, disc degeneration, spinal sarcopenia, and lumbar stenosis under spinal degenerative diseases (SDD), introducing the concept of the gutspine axis for the first time

Aging 5:6371 Fava M, Borus JS, Alpert JE, Nierenberg AA, Rosenbaum JF, Bottiglieri T (1997) Folate, vitamin B12, and homocysteine in major depressive disorder

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Progressive loading and strength work Controlled, progressive loading is what restores tendon, ligament, and muscle capacity around the knee