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For example, changes in both the presynaptic adhesion molecule neurexins and the postsynaptic adhesion molecule neuroligins have been observed to be associated with changes in synaptic plasticity in early life stress, stressed-sedentary, Parkinsons disease, and Alzheimers disease [54,55,56,57,58]

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*A phase 1 study evaluated the pharmacokinetic profile, safety, tolerability, and immunogenicity of the doses of AJOVY tested in the phase 2 and 3 trials (225 mg and 675 mg) following single administration in healthy subjects