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However, extending to biweekly dosing would result in greater fluctuations in plasma concentrations, with potentially subtherapeutic levels occurring before the next dose

7.5 Nitrite oxide assay In the presence of amino-4-benzene sulfonamide and N-(naphthyl-1)-diamino-1,2-ethane dichloride (N-1-naphthyl ethylene diamine) in an acidic medium, nitrites undergo a diazotization reaction