The binding site in S for COPI is sub-optimal The COPI binding region comprises KLHYT which differs somewhat from the canonical KXKXX or KKXX C-terminal COPI binding motif 35,39 , and it has been speculated for SARS-CoV that this non-canonical motif might allow more S to reach the surface, although this was not tested experimentally 20
Key actions: Local delivery of zinc, scavenging of free radicals, reduced inflammation, and promotion of mucosal healing
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The abrupt cessation of GLP-1R agonists in individuals with metabolic disorders may lead to adverse effects, as seen in a case where a patient developed IIH after discontinuing duraglutide [29]
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