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Finally, in the long term, as highlighted in the 20-year follow-up of the DPP (DPPOS, Diabetes Prevention Program Outcomes Study), neither metformin nor lifestyle intervention modified cardiovascular risk [38, 45] in line with previous studies [46,47,48,49]

Its also advisable to avoid drinking alcohol excessively, as it can interfere with the weight loss process and potentially lead to undesirable side effects when combined with GLP-1s

This is best achieved with either MDI of subcutaneous basal insulin analogues and mealtime rapid-acting or ultra-rapid-acting insulin analogues, or with continuous subcutaneous insulin infusion of a rapid-acting insulin analogue via a pump, delivered as continuous basal insulin combined with manual mealtime boluses

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Hanusch-Enserer U, Brabant G, Rodenn M