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doi: 10.3390/nu13124469 37

Class I antiarrhythmic drugs are contraindicated due to increased risk for arrhythmia-associated sudden cardiac death as shown in the Cardiac Arrhythmia Suppression Trial (CAST) [92]

Future investigations should integrate cutting-edge approaches (e.g., single-cell RNA sequencing, spatial transcriptomics) with dynamic molecular mechanism analyses to systematically unravel the molecular interaction networks and signaling pathways underlying ESCM efficacy