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China Patent Application CN103,695,506 (A) Additional information Maximilian Schmacht and Eric Lorenz have contributed equally to this article

More importantly, although AICAR acts on PARP-1 phosphorylation and ABCA1 protein level in the presence or absence of PARP1 treatment, the effects of AICAR could be partially attenuated by PARP-1 treatment

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When gut bacteria ferment dietary fiber in the colon, they produce these SCFAs, which directly activate L-cells to secrete GLP-1