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GR can perform its enzymatic activity in the cytoplasm, but also in the ER and within lysosomes, mitochondria and the nucleus

doi: 10.3389/fchem.2019.00558 Received 31 May 2019 Accepted 22 July 2019 Published 13 August 2019 Volume 7 - 2019 Edited by Chiung-Wen Hu, Chung Shan Medical University, Taiwan Reviewed by Qingping Wang, Sanofi, United States

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The predominantly alpha-helical C-terminal domain is involved with the binding of hydrophobic substrates (such as hydrophobic portions of xenobiotics)