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It only requires that each axis is real enough to make best drug for me a different question than best drug overall, and on that narrower point, all five axes clear the bar

Epithalon, primarily known for its telomere-lengthening effects, also increases neurogenesis rates and accelerates neuron differentiation

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The FDA has formally recognized Model-Informed Drug Development (MIDD) under PDUFA VI as a tool for dose optimization, supportive efficacy evidence, and clinical trial design (Wang et al., 2019, DOI)