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Lipid peroxidation, created by free radicals attacking cell membranes, results in the production of lipid peroxidation derivatives, including 4-HNE, MDA, and many other toxic aldehydes.[] HNE can damage beta cells of the pancreas and impair the ability of muscle and the liver cells to respond to insulin

In order to determine whether Se supplementation may impact the progression of autoimmune thyroid disease, some trials carried out in regions where the population has a diffusely low or borderline Se status inconsistently suggest that Se supplementation may cause a decrease in thyroid autoantibodies (243, 244)

Moreover, 30% of ME/CFS patients in one study were identified to have antibodies against endothelial cells (506)

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